Issue 48, 2011
From the journal:

Chemical Communications

Catalytic enantioselective addition of terminal 1,3-diynes to aromatic ketones: facile access to chiral nonracemic tertiary alcohols†

Tian-Lin Liu,a   Hai Ma,a   Fa-Guang Zhang,a   Yan Zheng,a   Jing Niea  and  Jun-An Ma*a  

* Corresponding authors

a Department of Chemistry, Tianjin University, Tianjin 300072, China
E-mail: majun_an68@tju.edu.cn
Fax: +86-22-2740-3475

Abstract

An efficient, catalytic, and enantioselective 1,2-addition of terminal 1,3-diynes to aromatic ketones was realized in the presence of 10 mol% of a Cu(OTf)2-hydroxycamphor-sulfonamide complex, affording chiral tertiary alcohols in up to 94% yield and 90% ee.

Graphical abstract: Catalytic enantioselective addition of terminal 1,3-diynes to aromatic ketones: facile access to chiral nonracemic tertiary alcohols

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Article information

DOI
https://doi.org/10.1039/C1CC15968B
Article type
Communication
Submitted
26 Sep 2011
Accepted
24 Oct 2011
First published
09 Nov 2011

Chem. Commun., 2011,47, 12873-12875

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Catalytic enantioselective addition of terminal 1,3-diynes to aromatic ketones: facile access to chiral nonracemic tertiary alcohols

T. Liu, H. Ma, F. Zhang, Y. Zheng, J. Nie and J. Ma, Chem. Commun., 2011, 47, 12873 DOI: 10.1039/C1CC15968B

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