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Issue 47, 2011
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Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides

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Abstract

Norbornapeptides (bicyclo[2.2.1]heptapeptides) and related bicyclic homodetic peptides were prepared by solid-phase peptide synthesis using an orthogonal protection scheme. These conformationally rigid peptides cover an almost pristine area of peptide topological space and adopt globular shapes similar to those of short α-helical peptides.

Graphical abstract: Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides

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Article information


Submitted
15 Sep 2011
Accepted
11 Oct 2011
First published
27 Oct 2011

Chem. Commun., 2011,47, 12634-12636
Article type
Communication

Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides

M. Bartoloni, R. U. Kadam, J. Schwartz, J. Furrer, T. Darbre and J. Reymond, Chem. Commun., 2011, 47, 12634
DOI: 10.1039/C1CC15704C

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