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Issue 44, 2011
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Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells

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Abstract

New 1,2-closo- and 7,8-nido-carboranylpyrazolopyrimidines bind to the translocator protein (TSPO) with high affinity, providing the first evidence of a unique two-site binding profile for the closo-carborane derivative. The boron-rich compounds can also deliver boron to human glioma cells far more effectively than clinical agents used in boron neutron capture therapy (BNCT).

Graphical abstract: Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells

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Article information


Submitted
27 Jul 2011
Accepted
20 Sep 2011
First published
13 Oct 2011

Chem. Commun., 2011,47, 12179-12181
Article type
Communication

Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells

E. L. Crossley, F. Issa, A. M. Scarf, M. Kassiou and L. M. Rendina, Chem. Commun., 2011, 47, 12179
DOI: 10.1039/C1CC14587H

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