Issue 37, 2011

An efficient synthesis of hydropyrido[1,2-a]indole-6(7H)-ones via an In(iii)-catalyzed tandem cyclopropane ring-opening/Friedel–Crafts alkylation sequence

Abstract

An efficient Lewis acid-catalyzed cyclopropane ring-opening/Friedel–Crafts alkylation sequence of methyl 1-(1H-indole-carbonyl)-1-cyclopropanecarboxylates is reported. The protocol affords functionalized hydropyrido[1,2-a]indole-6(7H)-ones in up to 99% yield.

Graphical abstract: An efficient synthesis of hydropyrido[1,2-a]indole-6(7H)-ones via an In(iii)-catalyzed tandem cyclopropane ring-opening/Friedel–Crafts alkylation sequence

Supplementary files

Additions and corrections

Article information

Article type
Communication
Submitted
09 Jul 2011
Accepted
28 Jul 2011
First published
22 Aug 2011

Chem. Commun., 2011,47, 10278-10280

An efficient synthesis of hydropyrido[1,2-a]indole-6(7H)-ones via an In(III)-catalyzed tandem cyclopropane ring-opening/Friedel–Crafts alkylation sequence

D. V. Patil, M. A. Cavitt, P. Grzybowski and S. France, Chem. Commun., 2011, 47, 10278 DOI: 10.1039/C1CC14131G

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