SiO2@Fe2O3 core–shell nanoparticles for covalent immobilization and release of sparfloxacin drug

Nadia E. A. El-Gamel; Laura Wortmann; Karim Arroub; Sanjay Mathur

doi:10.1039/C1CC13708E

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SiO₂@Fe₂O₃ core–shell nanoparticles for covalent immobilization and release of sparfloxacin drug†

Nadia E. A. El-Gamel,^a Laura Wortmann,^b Karim Arroub^b and Sanjay Mathur*^b

Author affiliations

* Corresponding authors

^a Chemistry Department, Faculty of Science, Cairo University, 12613 Giza, Egypt
E-mail: nadinealy@hotmail.com

^b Institute of Inorganic Chemistry, University of Cologne, Cologne 50939, Germany
E-mail: sanjay.mathur@uni-koeln.de
Fax: +49 2214704899

Abstract

Silica-coated Fe₂O₃ nanoparticles were synthesized as carriers for the covalent immobilization and release of antimicrobial drug sparfloxacin (SPFX). SPFX-loaded nanoparticles exhibited time-dependent drug release, with no measurable in vitro cytotoxicity, making the drug@nanoparticle conjugates potentially relevant for nanomedicine applications.

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Article information

DOI: https://doi.org/10.1039/C1CC13708E
Article type: Communication
Submitted: 21 Jun 2011
Accepted: 27 Jul 2011
First published: 10 Aug 2011

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Chem. Commun., 2011,47, 10076-10078

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SiO₂@Fe₂O₃ core–shell nanoparticles for covalent immobilization and release of sparfloxacin drug

N. E. A. El-Gamel, L. Wortmann, K. Arroub and S. Mathur, Chem. Commun., 2011, 47, 10076 DOI: 10.1039/C1CC13708E

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