Issue 36, 2011

Total synthesis of (−)-nakadomarin A

Abstract

A highly diastereoselective bifunctional organocatalyst controlled Michael addition, a nitro-Mannich/lactamization cascade, a furanN-acyliminium cyclisation, a sequential alkyne RCM/syn-reduction and an alkene RCM has allowed a 19 step, highly stereoselective synthesis of (−)-nakadomarin A.

Graphical abstract: Total synthesis of (−)-nakadomarin A

Supplementary files

Article information

Article type
Communication
Submitted
20 Jun 2011
Accepted
21 Jul 2011
First published
08 Aug 2011

Chem. Commun., 2011,47, 10037-10039

Total synthesis of (−)-nakadomarin A

A. F. Kyle, P. Jakubec, D. M. Cockfield, E. Cleator, J. Skidmore and D. J. Dixon, Chem. Commun., 2011, 47, 10037 DOI: 10.1039/C1CC13665H

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