Issue 39, 2011
From the journal:

Chemical Communications

Chemical engineering of Mycobacterium tuberculosisdodecin hybrids†

Xenia Vinzenz,a   Wolfgang Grosse,a   Uwe Linne,a   Britta Meissnera  and  Lars-Oliver Essen*a  

* Corresponding authors

a Philipps-Universität Marburg, Fachbereich Chemie, Hans-Meerwein-Strasse, 35032 Marburg, Germany
E-mail: essen@chemie.uni-marburg.de
Fax: +49 6421 22032
Tel: +49 6421 22191

Abstract

The suitability for chemical engineering of the highly symmetrical Mycobacterium tuberculosisdodecin was investigated, its inner cavity providing a large compartment shields introduced compounds from bulk solvent. Hybrids were obtained by S-alkylation of cysteine mutants and characterized by spectroscopic methods, including the crystal structures of wild type and biohybrid dodecins.

Graphical abstract: Chemical engineering of Mycobacterium tuberculosisdodecin hybrids

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Article information

DOI
https://doi.org/10.1039/C1CC12929E
Article type
Communication
Submitted
18 May 2011
Accepted
19 Aug 2011
First published
06 Sep 2011

Chem. Commun., 2011,47, 11071-11073

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Chemical engineering of Mycobacterium tuberculosisdodecin hybrids

X. Vinzenz, W. Grosse, U. Linne, B. Meissner and L. Essen, Chem. Commun., 2011, 47, 11071 DOI: 10.1039/C1CC12929E

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