Issue 33, 2011
From the journal:

Chemical Communications

A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles†

Wenru Zhao,*a   Hongti Zhang,a   Qianjun He,b   Yongsheng Li,a   Jinlou Gu,a   Liang Li,a   Hua Lia  and  Jianlin Shi*ab  

* Corresponding authors

a Advanced Functional Materials Laboratory, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 20023, China
E-mail: wenruru@ecust.edu.cn

b State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai 200050, China
E-mail: jlshi@sunm.shcnc.ac.cn

Abstract

A novel glucose-responsive controlled release of insulin system is constructed through coating enzyme multilayers on mesoporous silica particles (MSPs). The MSPs serve as the drug reservoir, and the enzyme multilayers cross-linked with glutaraldehyde act as a valve to control the release of insulin in response to the external glucose level.

Graphical abstract: A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles

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Article information

DOI
https://doi.org/10.1039/C1CC12740C
Article type
Communication
Submitted
10 May 2011
Accepted
15 Jun 2011
First published
22 Jul 2011

Chem. Commun., 2011,47, 9459-9461

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A glucose-responsive controlled release of insulin system based on enzyme multilayers-coated mesoporous silica particles

W. Zhao, H. Zhang, Q. He, Y. Li, J. Gu, L. Li, H. Li and J. Shi, Chem. Commun., 2011, 47, 9459 DOI: 10.1039/C1CC12740C

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