Issue 28, 2011
From the journal:

Chemical Communications

Morpholine catalyzed direct C3 alkenylation of indoles with α,β-unsaturated aldehydes†

Shi-Kai Xiang,a   Bo Zhang,a   Li-He Zhang,a   Yuxin Cuia  and  Ning Jiao*ab  

* Corresponding authors

a State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, China
E-mail: jiaoning@bjmu.edu.cn
Fax: (+86)-010-8280-5297
Tel: (+86) 01082805297

b Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062, China

Abstract

Organocatalytic direct C3 alkenylation of indoles has been developed. Simple and readily available morpholine trifluoroacetic acid salt is employed as an efficient catalyst in this oxidative dehydrogenative reaction. Simplicity and practicality constitute the most attractive advantages of this reaction.

Graphical abstract: Morpholine catalyzed direct C3 alkenylation of indoles with α,β-unsaturated aldehydes

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Article information

DOI
https://doi.org/10.1039/C1CC12220G
Article type
Communication
Submitted
18 Apr 2011
Accepted
26 May 2011
First published
20 Jun 2011

Chem. Commun., 2011,47, 8097-8099

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Morpholine catalyzed direct C3 alkenylation of indoles with α,β-unsaturated aldehydes

S. Xiang, B. Zhang, L. Zhang, Y. Cui and N. Jiao, Chem. Commun., 2011, 47, 8097 DOI: 10.1039/C1CC12220G

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