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Issue 33, 2011
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Creation of novel signalling modulators from existing cytokine using scanning motif-programming

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Abstract

We created two artificial modulating proteins for bone morphogenetic protein (BMP)-signalling, tmw57 and tmw61, starting from partial sequences of human BMP-2 (hBMP-2). The proteins were able to boost the hBMP-4 activities, BMP responsive element-driven transcription and an osteoblastic differentiation marker induction.

Graphical abstract: Creation of novel signalling modulators from existing cytokine using scanning motif-programming

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Article information


Submitted
18 Apr 2011
Accepted
04 Jul 2011
First published
18 Jul 2011

Chem. Commun., 2011,47, 9357-9359
Article type
Communication

Creation of novel signalling modulators from existing cytokine using scanning motif-programming

T. Murakami, K. Kashiwagi and K. Shiba, Chem. Commun., 2011, 47, 9357
DOI: 10.1039/C1CC12214B

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