Issue 32, 2011
From the journal:

Chemical Communications

Simple synthesis of 1,3-cyclopentanedione derived probes for labelingsulfenic acid proteins†

Jiang Qian,a   Chananat Klomsiri,b   Marcus W. Wright,c   S. Bruce King,c   Allen W. Tsang,a   Leslie B. Pooleb  and  Cristina M. Furdui*a  

* Corresponding authors

a Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, USA
E-mail: cfurdui@wfubmc.edu
Fax: +1 336 716-1214
Tel: +1 336 716-2697

b Department of Biochemistry, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, USA

c Department of Chemistry, Wake Forest University, Winston-Salem, USA

Abstract

Facile, two-step synthesis and kinetic characterization of new chemical probes for selective labeling of sulfenic acid (–SOH) in proteins are presented. The synthesis route relies on the simple and highly efficient Michael addition of thiol containing tags or linkers to 4-cyclopentene-1,3-dione, the unsaturated derivative of 1,3-cyclopentanedione.

Graphical abstract: Simple synthesis of 1,3-cyclopentanedione derived probes for labelingsulfenic acid proteins

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Article information

DOI
https://doi.org/10.1039/C1CC12127H
Article type
Communication
Submitted
13 Apr 2011
Accepted
22 Jun 2011
First published
08 Jul 2011

Chem. Commun., 2011,47, 9203-9205

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Simple synthesis of 1,3-cyclopentanedione derived probes for labelingsulfenic acid proteins

J. Qian, C. Klomsiri, M. W. Wright, S. B. King, A. W. Tsang, L. B. Poole and C. M. Furdui, Chem. Commun., 2011, 47, 9203 DOI: 10.1039/C1CC12127H

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