Issue 30, 2011

De novo synthesis of natural productsvia the asymmetric hydration of polyenes

Abstract

For the last ten years our group has been working toward the development of an asymmetric hydration approach to polyketide natural products based on the regioselective hydration of di- and tri-enoates. Key to the success of this approach is the recognition that both high regiocontrol and asymmetric induction could be obtained by the use of a Sharpless asymmetric dihydroxylation reaction. Herein we describe the development of the method and its application to natural product total synthesis.

Graphical abstract: De novo synthesis of natural productsvia the asymmetric hydration of polyenes

Article information

Article type
Feature Article
Submitted
30 Mar 2011
Accepted
18 Apr 2011
First published
11 May 2011

Chem. Commun., 2011,47, 8493-8505

De novo synthesis of natural productsvia the asymmetric hydration of polyenes

Y. Wang, Y. Xing, Q. Zhang and G. A. O'Doherty, Chem. Commun., 2011, 47, 8493 DOI: 10.1039/C1CC11791B

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