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Issue 26, 2011
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Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling

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Abstract

The combination of theoretical and computational studies with organic synthesis and biological investigations has led to exo-cyclopamine. This stable and highly potent derivative of cyclopamine promises big potential as an experimental drug against several types of human cancer.

Graphical abstract: Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling

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Article information


Submitted
29 Mar 2011
Accepted
22 Apr 2011
First published
17 May 2011

Chem. Commun., 2011,47, 7362-7364
Article type
Communication

Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling

P. Heretsch, A. Büttner, L. Tzagkaroulaki, S. Zahn, B. Kirchner and A. Giannis, Chem. Commun., 2011, 47, 7362
DOI: 10.1039/C1CC11782C

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