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Issue 26, 2011
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Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling

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Abstract

The combination of theoretical and computational studies with organic synthesis and biological investigations has led to exo-cyclopamine. This stable and highly potent derivative of cyclopamine promises big potential as an experimental drug against several types of human cancer.

Graphical abstract: Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling

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Publication details

The article was received on 29 Mar 2011, accepted on 22 Apr 2011 and first published on 17 May 2011


Article type: Communication
DOI: 10.1039/C1CC11782C
Citation: Chem. Commun., 2011,47, 7362-7364
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    Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling

    P. Heretsch, A. Büttner, L. Tzagkaroulaki, S. Zahn, B. Kirchner and A. Giannis, Chem. Commun., 2011, 47, 7362
    DOI: 10.1039/C1CC11782C

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