Issue 23, 2011
From the journal:

Chemical Communications

The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source†

Xinyi Ren,a   Jianbin Chen,a   Fan Chen*a  and  Jiang Cheng*a  

* Corresponding authors

a College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 3250, People's Republic of China
E-mail: jiangcheng@wzu.edu.cn, fanchen@wzu.edu.cn

Abstract

A palladium-catalyzed cyanation of the 3-position of indole sp2 C–H bonds by the combination of NH4HCO3 and DMSO as the “CN” source was achieved to provide aromatic nitriles in moderate to good yields with excellent regioselectivity. It represents a practical and safe cyanation method.

Graphical abstract: The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source

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Article information

DOI
https://doi.org/10.1039/C1CC11603G
Article type
Communication
Submitted
20 Mar 2011
Accepted
19 Apr 2011
First published
10 May 2011

Chem. Commun., 2011,47, 6725-6727

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The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source

X. Ren, J. Chen, F. Chen and J. Cheng, Chem. Commun., 2011, 47, 6725 DOI: 10.1039/C1CC11603G

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