Issue 18, 2011
From the journal:

Chemical Communications

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase†

Guillaume Mercey,ab   Tristan Verdelet,ab   Géraldine Saint-André,c   Emilie Gillon,d   Alain Wagner,c   Rachid Baati,c   Ludovic Jean,ab   Florian Nachond  and  Pierre-Yves Renard*abe  

* Corresponding authors

a CNRS UMR 6014-COBRA & FR 3038, IRCOF, Rue Lucien Tesnière, 76821 Mont Saint Aignan, France
E-mail: pierre-yves.renard@univ-rouen.fr
Fax: +33 2 35 52 29 71
Tel: +33 2 35 52 24 76

b Université de Rouen, Place Emile Blondel, 76821 Mont Saint Aignan, France

c Laboratoire de Chimie des Systèmes Fonctionnels, CNRS UMR 7199, Faculté de Pharmacie, Université de Strasbourg, BP 24, 67401 Illkirch, France

d Cellule enzymologie, Département de Toxicologie, Institut de Recherche Biomédicale des Armées, 24, Avenue des Maquis du Grésivaudan, BP87, 38702 La Tronche, France

e Institut Universitaire de France, 103, Boulevard Saint Michel, 75005 Paris, France

Abstract

Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLö-7.

Graphical abstract: First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC10787A
Article type
Communication
Submitted
10 Feb 2011
Accepted
15 Mar 2011
First published
31 Mar 2011

Chem. Commun., 2011,47, 5295-5297

Permissions

Request permissions

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

G. Mercey, T. Verdelet, G. Saint-André, E. Gillon, A. Wagner, R. Baati, L. Jean, F. Nachon and P. Renard, Chem. Commun., 2011, 47, 5295 DOI: 10.1039/C1CC10787A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements