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Issue 15, 2011
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One-pot nitro-Mannich/hydroamination cascades for the direct synthesis of 2,5-disubstituted pyrroles using base and gold catalysis

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Abstract

An efficient, easy to perform, one-pot reaction cascade for the synthesis of 2,5-disubstituted pyrroles from p-toluenesulfonyl protected imines and 4-nitrobut-1-yne under a combination of base and gold(III) catalysis is reported.

Graphical abstract: One-pot nitro-Mannich/hydroamination cascades for the direct synthesis of 2,5-disubstituted pyrroles using base and gold catalysis

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Article information


Submitted
08 Feb 2011
Accepted
15 Feb 2011
First published
28 Mar 2011

Chem. Commun., 2011,47, 4379-4381
Article type
Communication

One-pot nitro-Mannich/hydroamination cascades for the direct synthesis of 2,5-disubstituted pyrroles using base and gold catalysis

D. M. Barber, H. Sanganee and D. J. Dixon, Chem. Commun., 2011, 47, 4379
DOI: 10.1039/C1CC10751H

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