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Issue 12, 2011
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Hypervalent phenyl-λ3-iodane-mediated para-selective aromatic fluorination of 3-phenylpropyl ethers

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Abstract

Exposure of 3-phenylpropyl ethers to an activated iodosylbenzene monomer·18-crown-6 complex [PhI(OH)BF4·18C6] in the presence of BF3–Et2O and water results in the para-selective monofluorination of benzene ringvia neighboring alkoxy group participation and directly affords 3-(4-fluorophenyl)propyl ethers regioselectively in good yields.

Graphical abstract: Hypervalent phenyl-λ3-iodane-mediated para-selective aromatic fluorination of 3-phenylpropyl ethers

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Publication details

The article was received on 12 Jan 2011, accepted on 07 Feb 2011 and first published on 21 Feb 2011


Article type: Communication
DOI: 10.1039/C1CC10215J
Citation: Chem. Commun., 2011,47, 3410-3412

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    Hypervalent phenyl-λ3-iodane-mediated para-selective aromatic fluorination of 3-phenylpropyl ethers

    M. Saito, K. Miyamoto and M. Ochiai, Chem. Commun., 2011, 47, 3410
    DOI: 10.1039/C1CC10215J

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