Issue 18, 2011

Rational design of a Tn antigen mimic

Abstract

A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.

Graphical abstract: Rational design of a Tn antigen mimic

Supplementary files

Article information

Article type
Communication
Submitted
11 Jan 2011
Accepted
16 Mar 2011
First published
31 Mar 2011

Chem. Commun., 2011,47, 5319-5321

Rational design of a Tn antigen mimic

F. Corzana, J. H. Busto, F. Marcelo, M. García de Luis, J. L. Asensio, S. Martín-Santamaría, Y. Sáenz, C. Torres, J. Jiménez-Barbero, A. Avenoza and J. M. Peregrina, Chem. Commun., 2011, 47, 5319 DOI: 10.1039/C1CC10192G

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