Issue 18, 2011
From the journal:

Chemical Communications

A new strategy for a DNA assay based on a target-triggered isothermal exponential degradation reaction†

Jing Zhao,ab   Tao Liu,c   Qi Fanb  and  Genxi Li*ab  

* Corresponding authors

a Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China
E-mail: genxili@nju.edu.cn
Fax: +86-25-83592510

b Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China

c Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China

Abstract

An ultra-sensitive, fast, simple and easily operated method for sequence-specific detection of polynucleotides is proposed herein, which is based on a novel target-triggered isothermal exponential degradation reaction (TT-isoTexpDR) and the color change of probe-functionalized gold nanoparticles.

Graphical abstract: A new strategy for a DNA assay based on a target-triggered isothermal exponential degradation reaction

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Article information

DOI
https://doi.org/10.1039/C1CC10186B
Article type
Communication
Submitted
11 Jan 2011
Accepted
16 Mar 2011
First published
29 Mar 2011

Chem. Commun., 2011,47, 5262-5264

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A new strategy for a DNA assay based on a target-triggered isothermal exponential degradation reaction

J. Zhao, T. Liu, Q. Fan and G. Li, Chem. Commun., 2011, 47, 5262 DOI: 10.1039/C1CC10186B

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