Issue 12, 2011
From the journal:

Chemical Communications

Bimodal, dimetallic lanthanide complexes that bind to DNA: the nature of binding and its influence on water relaxivity†

Jennifer E. Jones,a   Angelo J. Amoroso,a   I. Mihaela Dorin,a   Giacomo Parigi,b   Benjamin D. Ward,a   Niklaas J. Buurma*a  and  Simon J. A. Pope*a  

* Corresponding authors

a School of Chemistry, Main Building, Cardiff University, Cardiff CF10 3AT, Cymru/Wales
E-mail: popesj@cardiff.ac.uk, buurma@cardiff.ac.uk
Fax: (44)2920874030
Tel: (44) 2920879316

b Magnetic Resonance Center, University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino (Fl), Italy

Abstract

UV-visible titrations, 1H NMRD experiments and molecular docking studies show that emissive anthraquinone appended dimetallic lanthanide complexes bind to DNA. The strength of binding and the observed relaxivity behaviour depend on the nature of the substituted anthraquinone core.

Graphical abstract: Bimodal, dimetallic lanthanide complexes that bind to DNA: the nature of binding and its influence on water relaxivity

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Article information

DOI
https://doi.org/10.1039/C1CC00111F
Article type
Communication
Submitted
06 Jan 2011
Accepted
31 Jan 2011
First published
21 Feb 2011

Chem. Commun., 2011,47, 3374-3376

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Bimodal, dimetallic lanthanide complexes that bind to DNA: the nature of binding and its influence on water relaxivity

J. E. Jones, A. J. Amoroso, I. M. Dorin, G. Parigi, B. D. Ward, N. J. Buurma and S. J. A. Pope, Chem. Commun., 2011, 47, 3374 DOI: 10.1039/C1CC00111F

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