Issue 12, 2011

An expeditious asymmetric synthesis of the pentacyclic core of the cortistatins by an intramolecular (4+3) cycloaddition

Abstract

A concise, asymmetric synthesis of the pentacyclic framework of the cortistatins has been accomplished in 12 steps from commercially available starting materials, employing a highly diastereoselective intramolecular (4+3) cycloaddition of epoxy enolsilanes as the key step.

Graphical abstract: An expeditious asymmetric synthesis of the pentacyclic core of the cortistatins by an intramolecular (4+3) cycloaddition

Supplementary files

Article information

Article type
Communication
Submitted
05 Jan 2011
Accepted
26 Jan 2011
First published
11 Feb 2011

Chem. Commun., 2011,47, 3416-3417

An expeditious asymmetric synthesis of the pentacyclic core of the cortistatins by an intramolecular (4+3) cycloaddition

L. L. Liu and P. Chiu, Chem. Commun., 2011, 47, 3416 DOI: 10.1039/C1CC00087J

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