Issue 14, 2011
From the journal:

Chemical Communications

Kinetic resolution of racemic amines using provisional molecular chirality generated by spontaneous crystallization†

Masami Sakamoto,*a   Kazuyuki Fujita,a   Fumitoshi Yagishita,a   Atsushi Unosawa,a   Takashi Minoa  and  Tsutomu Fujitaa  

* Corresponding authors

a Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan
E-mail: sakamotom@faculty.chiba-u.jp

Abstract

N-(2-methoxy-1-naphthoyl)pyrrolidine afforded chiral crystals by spontaneous crystallization. The molecular chirality in the crystal was retained after dissolving the crystals in a cooled solvent. Kinetic resolution of racemic amines was performed using the provisional chiral molecular conformation derived from chiral crystals.

Graphical abstract: Kinetic resolution of racemic amines using provisional molecular chirality generated by spontaneous crystallization

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Article information

DOI
https://doi.org/10.1039/C1CC00081K
Article type
Communication
Submitted
05 Jan 2011
Accepted
17 Feb 2011
First published
07 Mar 2011

Chem. Commun., 2011,47, 4267-4269

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Kinetic resolution of racemic amines using provisional molecular chirality generated by spontaneous crystallization

M. Sakamoto, K. Fujita, F. Yagishita, A. Unosawa, T. Mino and T. Fujita, Chem. Commun., 2011, 47, 4267 DOI: 10.1039/C1CC00081K

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