Issue 12, 2011
From the journal:

Chemical Communications

First one-pot stereoselective synthesis of cis-2,3-dihydro-4-perfluoroalkyl-1H-1,5-benzodiazepines via a catalyst-free three-component reaction†

Jiechao Xu,a   Jiamei Wei,a   Linglin Bian,a   Jiaping Zhang,a   Jie Chen,a   Hongmei Deng,a   Xiaoyu Wu,*a   Hui Zhang*a  and  Weiguo Cao*abc  

* Corresponding authors

a Department of Chemistry, Shanghai University, 99 Shangda Rd, Shanghai 200444, People's Republic of China
E-mail: wgcao@staff.shu.edu.cn, yehao7171@shu.edu.cn, wuxy@shu.edu.cn
Fax: +86 21-66134856

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, People's Republic of China

c Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, People's Republic of China

Abstract

cis-2,3-Dihydro-4-perfluoroalkyl-1H-1,5-benzodiazepines were stereoselectively synthesized using a one-pot, catalyst-free, three-component reaction. This novel, efficient and convenient approach was used to synthesize 22 related products in moderate to excellent yields, demonstrating the scope and potential economic impact of the reaction.

Graphical abstract: First one-pot stereoselective synthesis of cis-2,3-dihydro-4-perfluoroalkyl-1H-1,5-benzodiazepines via a catalyst-free three-component reaction

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Article information

DOI
https://doi.org/10.1039/C0CC05039C
Article type
Communication
Submitted
19 Nov 2010
Accepted
21 Jan 2011
First published
07 Feb 2011

Chem. Commun., 2011,47, 3607-3609

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First one-pot stereoselective synthesis of cis-2,3-dihydro-4-perfluoroalkyl-1H-1,5-benzodiazepines via a catalyst-free three-component reaction

J. Xu, J. Wei, L. Bian, J. Zhang, J. Chen, H. Deng, X. Wu, H. Zhang and W. Cao, Chem. Commun., 2011, 47, 3607 DOI: 10.1039/C0CC05039C

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