Jump to main content
Jump to site search

Issue 10, 2011
Previous Article Next Article

PET imaging of nobiletin based on a practical total synthesis

Author affiliations

Abstract

A practical synthesis of nobiletin, a polymethoxylated citrus flavone, was accomplished by utilizing our novel flavone synthesis. Synthetic nobiletin was labelled by selective demethylation and rapid incorporation of 11C atom. Positron emission tomography images successfully visualized the brain distribution, which may provide therapeutic benefits in the treatment of Alzheimer's disease.

Graphical abstract: PET imaging of nobiletin based on a practical total synthesis

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Nov 2010, accepted on 20 Dec 2010 and first published on 18 Jan 2011


Article type: Communication
DOI: 10.1039/C0CC04936K
Chem. Commun., 2011,47, 2868-2870

  •   Request permissions

    PET imaging of nobiletin based on a practical total synthesis

    T. Asakawa, A. Hiza, M. Nakayama, M. Inai, D. Oyama, H. Koide, K. Shimizu, T. Wakimoto, N. Harada, H. Tsukada, N. Oku and T. Kan, Chem. Commun., 2011, 47, 2868
    DOI: 10.1039/C0CC04936K

Search articles by author

Spotlight

Advertisements