Issue 12, 2011
From the journal:

Chemical Communications

Angiogenin induces nitric oxide release independently from its RNase activity†

Raphaël Trouillon,*a   Dong-Ku Kang,‡b   Soo-Ik Changb  and  Danny O'Harea  

* Corresponding authors

a Department of Bioengineering, Imperial College London, London, UK
E-mail: raphael.trouillon06@imperial.ac.uk
Fax: +44 (0)20 7594 5177
Tel: +44 (0)20 7594 6498

b Department of Biochemistry, Chungbuk National University, Cheongju, Republic of Korea

Abstract

Nitric oxide (NO), a biological mediator involved in vascular physiology, was sensed electrochemically using a microelectrode array. Angiogenin was shown to trigger nitric oxide synthase (NOS) activity in human umbilical vein endothelial cells and embryonic stem cell derived endothelial cells independently from its RNase activity.

Graphical abstract: Angiogenin induces nitric oxide release independently from its RNase activity

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Article information

DOI
https://doi.org/10.1039/C0CC04527F
Article type
Communication
Submitted
20 Oct 2010
Accepted
12 Jan 2011
First published
31 Jan 2011

Chem. Commun., 2011,47, 3421-3423

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Angiogenin induces nitric oxide release independently from its RNase activity

R. Trouillon, D. Kang, S. Chang and D. O'Hare, Chem. Commun., 2011, 47, 3421 DOI: 10.1039/C0CC04527F

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