Issue 9, 2011
From the journal:

Chemical Communications

Effects of local electric fields on the redox free energy of single stranded DNA†

Marco D'Abramo,*ab   Modesto Orozcoa  and  Andrea Amadei*c  

* Corresponding authors

a Departamento de Bioquímica y Biología Molecular Universitat de Barcelona, Avinguda Diagonal, Barcelona, Spain

b Computational Biophysics Group, Spanish National Cancer Research Centre (CNIO), C/ Melchor Fernandez Almagro 3, Madrid, Spain
E-mail: marco.dabramo.cnio@gmail.com
Tel: +34 91 7328000 (3081)

c Dipartimento di Scienze e Tecnologie Chimiche, Universita‘ di Roma Tor Vergata, Via della ricerca scientifica, Rome, Italy
E-mail: andrea.amadei@uniroma2.it

Abstract

Influence of external electric field as well as base substitution effects on the reduction/oxidation free energies of single stranded DNA suggest that base sequencing via measuring redox properties might be feasible under the conditions that (i) a difference of ∼ 230 kJ mol−1 in the oxidation potentials is enough to discriminate between nucleobases conductance signals and (ii) the strand is long enough to reduce end effects.

Graphical abstract: Effects of local electric fields on the redox free energy of single stranded DNA

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Article information

DOI
https://doi.org/10.1039/C0CC04352D
Article type
Communication
Submitted
11 Oct 2010
Accepted
22 Nov 2010
First published
23 Dec 2010

Chem. Commun., 2011,47, 2646-2648

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Effects of local electric fields on the redox free energy of single stranded DNA

M. D'Abramo, M. Orozco and A. Amadei, Chem. Commun., 2011, 47, 2646 DOI: 10.1039/C0CC04352D

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