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Issue 9, 2011
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The tightly regulated copper window in yeast

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Abstract

The two opposing yeast copper regulators, Ace1 and Mac1, were converted into two fluorescent probes, Ace1-FRET and Mac1-FRET, which selectively and sensitively respond to Cu+. The Cu+-binding curves obtained for both regulators as well as for the copper storage proteins Cup1 and Crs5 show that free copper(I) is maintained in a narrow window inside yeast.

Graphical abstract: The tightly regulated copper window in yeast

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Article information


Submitted
08 Oct 2010
Accepted
07 Dec 2010
First published
21 Dec 2010

Chem. Commun., 2011,47, 2571-2573
Article type
Communication

The tightly regulated copper window in yeast

S. V. Wegner, F. Sun, N. Hernandez and C. He, Chem. Commun., 2011, 47, 2571
DOI: 10.1039/C0CC04292G

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