Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action

Hui Ming Ge; Wei Yan; Zhi Kai Guo; Qiong Luo; Rui Feng; Le Yun Zang; Yan Shen; Rui Hua Jiao; Qiang Xu; Ren Xiang Tan

doi:10.1039/C0CC04183A

Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action†

Hui Ming Ge,^a Wei Yan,^ab Zhi Kai Guo,^a Qiong Luo,^a Rui Feng,^a Le Yun Zang,^ab Yan Shen,^a Rui Hua Jiao,^a Qiang Xu^a and Ren Xiang Tan*^a

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^a Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
E-mail: rxtan@nju.edu.cn
Fax: +86 25-83302728
Tel: +86 25-83592945

^b State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Abstract

Precursor-fed cultivation of endophytic Chaetomium globosum1C51 afforded nine novel “unnatural” halogenated chaetoglobosins including those with more preferable immunosuppressive activity.

Chemical Communications

Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action†

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Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action

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