Palladium catalyzed ring opening of furans as a route to α,β-unsaturated aldehydes

Abstract

Furans may be ring opened via pallado-catalyzed reactions leading to α,β-unsaturated aldehydes and ketones tethered to indole and isoquinoline moieties. Besides their synthetic interest, these fragmentations bring interesting elements into the discussion around the reaction mechanisms involved in palladium C–H activations of electron-rich heterocycles.