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Issue 4, 2011
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Neojaponicone A, a bioactive sesquiterpene lactone dimer with an unprecedented carbon skeleton from Inula japonica

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Abstract

Five new dimeric sesquiterpene lactones, neojaponicone A (1) and japonicones M–P (2–5) were isolated from the aerial part of Inula japonica.Neojaponicone A (1) has an unprecedented carbon skeleton with an unusual valerolactone system formed between a guaianolide and an eudesmane. The structure and absolute configuration of 1 were established by extensive analysis of spectroscopic data and computational approaches.

Graphical abstract: Neojaponicone A, a bioactive sesquiterpene lactone dimer with an unprecedented carbon skeleton from Inula japonica

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Article information


Submitted
31 Aug 2010
Accepted
12 Oct 2010
First published
23 Nov 2010

Chem. Commun., 2011,47, 1222-1224
Article type
Communication

Neojaponicone A, a bioactive sesquiterpene lactone dimer with an unprecedented carbon skeleton from Inula japonica

J. J. Qin, L. Y. Wang, J. X. Zhu, H. Z. Jin, J. J. Fu, X. F. Liu, H. L. Li and W. D. Zhang, Chem. Commun., 2011, 47, 1222
DOI: 10.1039/C0CC03572F

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