Issue 4, 2011
From the journal:

Chemical Communications

Neojaponicone A, a bioactive sesquiterpene lactone dimer with an unprecedented carbon skeleton from Inula japonica†

Jiang Jiang Qin,‡a   Li Yan Wang,‡b   Jia Xian Zhu,a   Hui Zi Jin,*a   Jian Jun Fu,a   Xiao Feng Liu,b   Hong Lin Lib  and  Wei Dong Zhang*ac  

* Corresponding authors

a School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P. R. China
E-mail: wdzhangy@hotmail.com, kimhz@sjtu.edu.cn
Fax: +86 (0)21 8187 1244
Tel: +86 (0)21 8187 1244

b Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, P. R. China

c Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China

Abstract

Five new dimeric sesquiterpene lactones, neojaponicone A (1) and japonicones M–P (2–5) were isolated from the aerial part of Inula japonica.Neojaponicone A (1) has an unprecedented carbon skeleton with an unusual valerolactone system formed between a guaianolide and an eudesmane. The structure and absolute configuration of 1 were established by extensive analysis of spectroscopic data and computational approaches.

Graphical abstract: Neojaponicone A, a bioactive sesquiterpene lactone dimer with an unprecedented carbon skeleton from Inula japonica

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Article information

DOI
https://doi.org/10.1039/C0CC03572F
Article type
Communication
Submitted
31 Aug 2010
Accepted
12 Oct 2010
First published
23 Nov 2010

Chem. Commun., 2011,47, 1222-1224

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Neojaponicone A, a bioactive sesquiterpene lactone dimer with an unprecedented carbon skeleton from Inula japonica

J. J. Qin, L. Y. Wang, J. X. Zhu, H. Z. Jin, J. J. Fu, X. F. Liu, H. L. Li and W. D. Zhang, Chem. Commun., 2011, 47, 1222 DOI: 10.1039/C0CC03572F

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