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Issue 11, 2011
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A simple and high-throughput method of ultrasonic extraction-capillary electrophoresis for determination of melamine in milk

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Abstract

A simple, rapid, sensitive, and low cost method of ultrasonic extraction (USE) and capillary electrophoresis (CE) for the determination of melamine in milk is developed. The most widely used extraction methods of melamine (SPE and LLE) were compared with ultrasonic-assisted extraction by evaluating simplicity, cost and sample clean-up effect, and the conditions of CE were optimized. The melamine was extracted by acetonitrile under the action of ultrasonic energy. After centrifuging, diluting and filtering, the extract was analyzed by CE directly. The determination used 20 mM NaH2PO4 as running buffer (pH 2.6), UV detection at 208 nm, and an applied voltage of 18 kV. The proposed method demonstrated good performance concerning linearity (R2 = 0.9989), precision (2.6–4.8%), limit of detection and quantification (LOD, 0.163 mg kg−1; LOQ, 0.542 mg kg−1) and accuracy (85.1–98.3%). The proposed method is rapid, convenient and low-cost for the determination of melamine in milk products.

Graphical abstract: A simple and high-throughput method of ultrasonic extraction-capillary electrophoresis for determination of melamine in milk

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Publication details

The article was received on 18 Jul 2011, accepted on 11 Aug 2011 and first published on 30 Sep 2011


Article type: Paper
DOI: 10.1039/C1AY05426K
Citation: Anal. Methods, 2011,3, 2557-2561

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    A simple and high-throughput method of ultrasonic extraction-capillary electrophoresis for determination of melamine in milk

    Y. Lv, Y. Sun, L. Wang, C. Jia and H. Sun, Anal. Methods, 2011, 3, 2557
    DOI: 10.1039/C1AY05426K

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