Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 12, 2011

Optimization of micellar LC conditions for separation of opium alkaloids and their determination in pharmaceutical preparations

Author affiliations

Abstract

Micellar liquid chromatography (MLC) has been developed for the analysis of opium alkaloids. The composition of micellar mobile phase for the separation of morphine, codeine, papaverine and noscapine have been optimized by a chemometric tool taking into account the efficiency and asymmetry of chromatographic peaks, resolution between each pair of peaks and total time of separation. The optimized mobile phase composition (0.10 M sodium dodecylsulfate (SDS), 5% (v/v) 1-butanol; pH 2.5) allows to fully separate alkaloids within 15 min. The proposed MLC method was validated, compared with the RP-HPLC method and successfully applied for the analysis of the pharmaceutical preparation “Omnopon, solution for injection”.

Graphical abstract: Optimization of micellar LC conditions for separation of opium alkaloids and their determination in pharmaceutical preparations

Article information


Submitted
29 Jun 2011
Accepted
05 Oct 2011
First published
03 Nov 2011

Anal. Methods, 2011,3, 2749-2757
Article type
Paper

Optimization of micellar LC conditions for separation of opium alkaloids and their determination in pharmaceutical preparations

A. U. Kulikov, A. P. Boichenko and A. G. Verushkin, Anal. Methods, 2011, 3, 2749 DOI: 10.1039/C1AY05389B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements