Issue 8, 2011
From the journal:

Analytical Methods

Tissue imprint imaging by desorption electrospray ionizationmass spectrometry

Demian R. Ifa,†ab   Amitava Srimany,a   Livia S. Eberlin,b   Hemanta R. Naik,a   Vasudeva Bhat,a   R. Graham Cooksb  and  T. Pradeep*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Madras, Chennai, India
E-mail: pradeep@iitm.ac.in
Fax: +91 44 2257-0545
Tel: +91 44 2257 4208

b Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN, USA
Fax: +1 765 494-9421
Tel: +1 765 494-5263

Abstract

Cross-sections of Myristica malabarica (Lam) seed and mouse brain tissue were imprinted on such ordinary surfaces as printer paper and TLC plates, and successfully imaged by desorption electrospray ionization mass spectrometry (DESI-MS) at 250 μm resolution. Chemical images representing the distribution of the alkaloid malabaricone C in the seed substructures and individual lipids in the substructures of the brain were obtained. Practical implications include analysis of irregular or soft materials, easy recording, transportation and storage of the latent image, and posterior analysis of the samples by different techniques without the requirement of addition of matrices or use of specific types of surfaces.

Graphical abstract: Tissue imprint imaging by desorption electrospray ionization mass spectrometry

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Article information

DOI
https://doi.org/10.1039/C1AY05295K
Article type
Technical Note
Submitted
17 May 2011
Accepted
18 Jun 2011
First published
18 Jul 2011

Anal. Methods, 2011,3, 1910-1912

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Tissue imprint imaging by desorption electrospray ionization mass spectrometry

D. R. Ifa, A. Srimany, L. S. Eberlin, H. R. Naik, V. Bhat, R. G. Cooks and T. Pradeep, Anal. Methods, 2011, 3, 1910 DOI: 10.1039/C1AY05295K

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