Issue 10, 2011

Multi-walled carbon nanotubes/chitosanpolymer composite modified glassy carbon electrode for sensitive simultaneous determination of levodopa and morphine

Abstract

A modified electrode was constructed by coating of the glassy carbon surface with carbon nanotubes/chitosan (CNTs/CS) and used for sensitive and selective determination of levodopa (L-dopa) and morphine (MO) in a 0.1 M phosphate buffer (pH 7.0). The electrochemical response characteristics of the modified electrode toward L-dopa and MO were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CA) techniques. Under optimum conditions the sensor provided a linear CA response in the range of 1–360 μM with a detection limit of 0.86 μM for L-dopa, and in the range of 1–240 μM, with a detection limit of 0.65 μM for MO. The designed sensor was used for determination of L-dopa and MO in human serum and urine with satisfactory results.

Graphical abstract: Multi-walled carbon nanotubes/chitosan polymer composite modified glassy carbon electrode for sensitive simultaneous determination of levodopa and morphine

Article information

Article type
Paper
Submitted
25 Apr 2011
Accepted
09 Aug 2011
First published
14 Sep 2011

Anal. Methods, 2011,3, 2400-2405

Multi-walled carbon nanotubes/chitosan polymer composite modified glassy carbon electrode for sensitive simultaneous determination of levodopa and morphine

A. Babaei and M. Babazadeh, Anal. Methods, 2011, 3, 2400 DOI: 10.1039/C1AY05241A

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