Issue 6, 2011

Electrochemical selection of G-quadruplex-binding ligands based on structure-switching of telomeric DNA

Abstract

Ligands that bind and stabilize G-quadruplex DNA structures are of significant interest because of their potential to inhibit telomerase and halt tumor cell proliferation. An electrochemical method was proposed to select natural G-quadruplex-binding ligands using ferrocene as the electrochemical indicator.

Graphical abstract: Electrochemical selection of G-quadruplex-binding ligands based on structure-switching of telomeric DNA

Article information

Article type
Communication
Submitted
26 Jan 2011
Accepted
18 Mar 2011
First published
06 Apr 2011

Anal. Methods, 2011,3, 1270-1273

Electrochemical selection of G-quadruplex-binding ligands based on structure-switching of telomeric DNA

X. Liu, Y. Jin, Y. Wang and Y. Qiao, Anal. Methods, 2011, 3, 1270 DOI: 10.1039/C1AY05046J

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