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Issue 2, 2011
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Liquid three-phase microextraction based on hollow fiber for highly selective and sensitive determination of desipramine using an ion selective electrode

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Abstract

In this paper, for the first time, a combination of hollow fiber based liquid 3-phase microextraction with a potentiometric method was applied as a highly selective and sensitive method of analysis. Desipramine, as a model compound, was extracted from a small volume in the presence of 0.10 mol L−1 NaOH (donor solution) through a thin phase of propyl benzoate inside the pores of a polypropylene hollow fiber and finally into a 10 μL acidic acceptor solution inside the hollow fiber. Two microelectrodes were designed and inserted into the two ends of a hollow fiber inside the acceptor solution. Potentiometric analysis was performed in situ within an extraction time of 15 min; the final stable signal was used for analytical application. Under the optimized conditions, an enrichment factor of 296 was achieved and the relative standard deviation (RSD%) of the method was 4.5%. The calibration curve was obtained in the range of 3.0 × 10−5 to 3.4 × 10−8 mol L−1 with a reasonable linearity (R2 > 0.9849) and a limit of detection (LOD) of 3.1 × 10−8 mol L−1. Finally, the applicability of the proposed method was evaluated by extraction and determination of desipramine in plasma and urine samples without any special pretreatment.

Graphical abstract: Liquid three-phase microextraction based on hollow fiber for highly selective and sensitive determination of desipramine using an ion selective electrode

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Article information


Submitted
26 Oct 2010
Accepted
12 Dec 2010
First published
06 Jan 2011

Anal. Methods, 2011,3, 463-470
Article type
Paper

Liquid three-phase microextraction based on hollow fiber for highly selective and sensitive determination of desipramine using an ion selective electrode

A. A. Ensafi, A. R. Allafchian, M. Saraji and S. Z. Mirahmadi Zare, Anal. Methods, 2011, 3, 463
DOI: 10.1039/C0AY00642D

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