Jump to main content
Jump to site search

Issue 22, 2011
Previous Article Next Article

Evaluation of the potential of surface enhancement Raman spectroscopy for detection of tricyclic psychotropic drugs. Case studies on imipramine and its metabolite

Author affiliations

Abstract

The potential use of surface Raman enhanced spectroscopy (SERS) for confirmatory identification and the semi-quantitative analysis of selected tricyclic antidepressants (TCAs) is examined utilizing a conventional silver colloid. Raman and SERS spectra of aqueous solutions of imipramine (Imi) and its metabolite, desipramine (Des), were recorded as the function of concentration using NIR excitation. A good linear correlation is observed for the dependence of the SERS signal at 684 cm−1 (R2 = 0.9997) on Imi concentration over the range of 0.75–7.5 μM. The limit of detection of imipramine in the silver colloidal solution is 0.98 μM. SERS spectra of Imi and Des were also recorded for blood plasma samples without prior purification as well as after the use of standard solid phase extraction. All spectra show the characteristic spectral profile of the molecules and moreover, stronger signal enhancement is observed for Imi in the “raw” samples as opposed to Imi extracted from a biological matrix.

Graphical abstract: Evaluation of the potential of surface enhancement Raman spectroscopy for detection of tricyclic psychotropic drugs. Case studies on imipramine and its metabolite

Back to tab navigation

Supplementary files

Article information


Submitted
14 Jul 2011
Accepted
01 Sep 2011
First published
30 Sep 2011

Analyst, 2011,136, 4704-4709
Article type
Paper

Evaluation of the potential of surface enhancement Raman spectroscopy for detection of tricyclic psychotropic drugs. Case studies on imipramine and its metabolite

A. Jaworska, R. Wietecha-Posłuszny, M. Woźniakiewicz, P. Kościelniak and K. Malek, Analyst, 2011, 136, 4704
DOI: 10.1039/C1AN15598A

Social activity

Search articles by author

Spotlight

Advertisements