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Issue 18, 2011
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Quantitative detection of C-deuterated drugs by CARSmicroscopy and Raman microspectroscopy

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Abstract

The introduction of carbon-deuterium (C–D) bonds into drug compounds by organic synthesis is a non-invasive labelling approach, which does not alter the chemical and physiological properties of the drug itself. C-deuterated drugs exhibit characteristic vibrational signatures in the C–D stretching region around 2100–2300 cm−1, which avoids spectral interference with contributions from a complex biological environment. In this paper, the quantitative detection of C-deuterated drugs by Raman microspectroscopy and single-band CARS microscopy is examined. Concentration-dependent studies on drugs with aliphatic and aromatic C–D moieties were performed in a two-channel microfluidic chip, using the corresponding non-deuterated (C–H) isotopologues as an internal reference.

Graphical abstract: Quantitative detection of C-deuterated drugs by CARS microscopy and Raman microspectroscopy

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Article information


Submitted
29 Nov 2010
Accepted
22 Jun 2011
First published
25 Jul 2011

Analyst, 2011,136, 3686-3693
Article type
Paper

Quantitative detection of C-deuterated drugs by CARS microscopy and Raman microspectroscopy

G. Bergner, C. R. Albert, M. Schiller, G. Bringmann, T. Schirmeister, B. Dietzek, S. Niebling, S. Schlücker and J. Popp, Analyst, 2011, 136, 3686
DOI: 10.1039/C0AN00956C

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