Issue 8, 2011

A novel approach for the separation of neutral analytes by means of electrochemically assisted injection coupled to capillary electrophoresis-mass spectrometry

Abstract

A novel concept for capillary electrophoresis-mass spectrometry (CE-MS) studies of neutral analytes is presented. The experimental approach is based on the implementation of electrochemically assisted injection (EAI) which enables the generation of charged species from neutral analytes. In this way electrophoretic separations can be performed without the use of surfactants leading to an excellent compatibility with ESI-MS. Various ferrocene species have been used as model compounds to demonstrate the potential of the EAI-CE-MS technique.

Graphical abstract: A novel approach for the separation of neutral analytes by means of electrochemically assisted injection coupled to capillary electrophoresis-mass spectrometry

Article information

Article type
Communication
Submitted
12 Oct 2010
Accepted
31 Jan 2011
First published
15 Feb 2011

Analyst, 2011,136, 1562-1565

A novel approach for the separation of neutral analytes by means of electrochemically assisted injection coupled to capillary electrophoresis-mass spectrometry

R. Scholz and F. Matysik, Analyst, 2011, 136, 1562 DOI: 10.1039/C0AN00794C

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