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Issue 7, 2011
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Spray desorption collection: an alternative to swabbing for pharmaceutical cleaning validation

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Abstract

Spray Desorption Collection (SDC) allows for much larger areas of surfaces to be sampled compared to traditional swabbing techniques, providing a valuable pre-concentration advantage. Closely related to desorption electrospray ionization (DESI), analytes from the sample surface are collected onto a selected collection surface, which in a second step can be analyzed directly. Here we demonstrate the application of SDC as a large surface area sampling tool coupled with paper spray MS (PS-MS) and demonstrate its capabilities for cleaning validation of pharmaceutical equipment for both acidic and basic active ingredients from an aluminium surface.

Graphical abstract: Spray desorption collection: an alternative to swabbing for pharmaceutical cleaning validation

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Article information


Submitted
17 Sep 2010
Accepted
16 Dec 2010
First published
24 Jan 2011

Analyst, 2011,136, 1298-1301
Article type
Communication

Spray desorption collection: an alternative to swabbing for pharmaceutical cleaning validation

S. Jain, A. Heiser and A. R. Venter, Analyst, 2011, 136, 1298
DOI: 10.1039/C0AN00728E

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