Issue 4, 2011
From the journal:

Analyst

Multi-parameter determination of TNFα, PCT and CRP for point-of-care testing†

Petra M. Krämer,*a   Melanie Keß,‡a   Elisabeth Kremmerb  and  Sigurd Schulte-Hostedea  

* Corresponding authors

a Helmholtz Zentrum München—German Research Center for Environmental Health, Institute of Ecological Chemistry, Ingolstädter Landstraße 1, Neuherberg (Oberschleißheim), Germany
E-mail: kramer@helmholtz-muenchen.de
Fax: +49-(0)89-3187-3371
Tel: +49-(0)89-3187-2772

b Helmholtz Zentrum München—German Research Center for Environmental Health, Institute of Molecular Immunology, Marchioninistraße 25, Munich, Germany

Abstract

A proof of concept for the simultaneous multi-parameter determination of three inflammation and sepsis parameters—TNFα, PCT and CRP—using a compact optical immunosensor is demonstrated. Harmonized assay conditions revealed standard curves with test midpoints (IC50) of 380 µg L−1 for TNFα, 2300 µg L−1 for PCT, and 2645 µg L−1 for CRP.

Graphical abstract: Multi-parameter determination of TNFα, PCT and CRP for point-of-care testing

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C0AN00699H
Article type
Communication
Submitted
09 Sep 2010
Accepted
25 Nov 2010
First published
15 Dec 2010

Analyst, 2011,136, 692-695

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Multi-parameter determination of TNFα, PCT and CRP for point-of-care testing

P. M. Krämer, M. Keß, E. Kremmer and S. Schulte-Hostede, Analyst, 2011, 136, 692 DOI: 10.1039/C0AN00699H

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