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Issue 2, 2011
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Opto-electrochemical nanosensor array for remote DNA detection

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Abstract

A high-density array of opto-electrochemical nanosensors is presented for remote DNA detection. It was fabricated by chemical etching of a coherent optical fibre bundle to produce a nanotip array. The surface of the etched bundle was sputter-coated with a thin ITO layer which was eventually insulated by an electrophoretic paint. The fabrication steps produced a high-density array of electrochemical nanosensors which retains the optical fibre bundle architecture and its imaging properties. A DNA probe was then immobilized on the nanosensor array surface in a polypyrrole film by electropolymerisation. After hybridisation with the complementary sequence, detection of the strepavidin-R-phycoerythrin label is performed by fluorescence imaging through the optical fibre bundle itself. Control experiments and regeneration steps have also been successfully demonstrated on this nanostructured opto-electrochemical platform.

Graphical abstract: Opto-electrochemical nanosensor array for remote DNA detection

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Article information


Submitted
13 Jul 2010
Accepted
13 Sep 2010
First published
14 Oct 2010

Analyst, 2011,136, 327-331
Article type
Paper

Opto-electrochemical nanosensor array for remote DNA detection

F. Deiss, S. Laurent, E. Descamps, T. Livache and N. Sojic, Analyst, 2011, 136, 327
DOI: 10.1039/C0AN00501K

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