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Issue 19, 2010
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DNA-functionalized colloids: Physical properties and applications

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The specificity and reversibility of the hydrogen-bonding between two complementary strands in DNA make this bio-molecule a unique binding agent. When DNA is grafted to nano-and micrometer sized colloids it can lead to specific binding between particles coated with complementary strands of single-stranded DNA. DNA-coated colloids hold great promise as the building blocks of a new generation of complex, self-assembling colloidal materials. This brief review sketches the recent developments and present status of the research on DNA-coated colloids with special emphasis on their role as potential building blocks in complex, self-assembling materials and as highly sensitive bio-sensors. Although the present review cannot be comprehensive, it hopefully highlights the promise of DNA-coated colloids as versatile and still largely unexplored form of soft matter.

Graphical abstract: DNA-functionalized colloids: Physical properties and applications

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Article information

25 Jan 2010
04 May 2010
First published
14 Jun 2010

Soft Matter, 2010,6, 4647-4660
Article type
Review Article

DNA-functionalized colloids: Physical properties and applications

N. Geerts and E. Eiser, Soft Matter, 2010, 6, 4647
DOI: 10.1039/C001603A

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