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Issue 7, 2010
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Dendronized cavitands: A step towards a synthetic viral capsid?

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Abstract

Dendronized cavitands represent unique macromolecular hosts for encapsulation of biologically relevant guests. They combine the highly specific guest binding exhibited by deep-cavity cavitands, with the modular yet monodisperse macromolecular structure provided by dendrimers. Because these structures retain the ability to assemble into dimeric capsules, they resemble a simplified synthetic analog of viral capsids, displaying a modular, functionalizable outer coating while providing a protective cavity for a range of small-molecule payloads. This article highlights their preparation, their characterization, and their unique potential for probing in vivo drug delivery.

Graphical abstract: Dendronized cavitands: A step towards a synthetic viral capsid?

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Article information


Submitted
21 Oct 2009
Accepted
24 Dec 2009
First published
05 Feb 2010

Soft Matter, 2010,6, 1377-1382
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Dendronized cavitands: A step towards a synthetic viral capsid?

S. M. Grayson and B. C. Gibb, Soft Matter, 2010, 6, 1377
DOI: 10.1039/B921935H

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