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Issue 6, 2010
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Cell surface modification with polymers for biomedical studies

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Abstract

Surface modification of living cells with natural or synthetic polymers is a powerful and useful tool in biomedical science and engineering. Various functional groups and bioactive substances can be immobilized to the cell surface through covalent conjugation, hydrophobic interaction, or electrostatic interaction. In this review, we provide an overview of the methods and polymers employed in cell surface modification, including: (1) covalent conjugation utilizing amino groups of cell surface proteins, (2) hydrophobic interaction of amphiphilic polymers with a lipid bilayer membrane, and (3) electrostatic interactions between cationic polymers and a negatively charged cell surface. We also discuss their applications in studies on cell therapy, cellcell interaction analysis, cell arrangement, and lineage determination of stem cells.

Graphical abstract: Cell surface modification with polymers for biomedical studies

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Publication details

The article was received on 09 Jul 2009, accepted on 14 Dec 2009 and first published on 25 Jan 2010


Article type: Review Article
DOI: 10.1039/B913621E
Citation: Soft Matter, 2010,6, 1081-1091
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    Cell surface modification with polymers for biomedical studies

    Y. Teramura and H. Iwata, Soft Matter, 2010, 6, 1081
    DOI: 10.1039/B913621E

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