Issue 7, 2010
From the journal:

Soft Matter

Self-assembly hollow nanosphere for enzyme encapsulation†

Wei Ha,ab   Xian-Wei Meng,c   Quan Li,b   Min-Min Fan,c   Shu-Lin Peng,b   Li-Sheng Ding,b   Xuan Tian,a   Sheng Zhang*c  and  Bang-Jing Li*b  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

b Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
E-mail: libj@cib.ac.cn
Fax: (+86)28-85223843
Tel: +86-28-85223843

c State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Sichuan University, Chengdu 610065, China
E-mail: zslbj@163.com
Fax: +86-28-85400266
Tel: +86-28-85400266

Abstract

This paper studies a kind of self-assembled hollow nanosphere for L-asparaginase encapsulation, and it was found that the hollow spheres not only enable a high loading of enzyme, but also show semi-permeability which could prevent the enzyme from leaving while allowing substrates and products to pass through to maintain the enzyme activity, and the encapsulated L-asparaginase showed significantly higher stability.

Graphical abstract: Self-assembly hollow nanosphere for enzyme encapsulation

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Article information

DOI
https://doi.org/10.1039/B925747K
Article type
Communication
Submitted
08 Dec 2009
Accepted
30 Jan 2010
First published
11 Feb 2010

Soft Matter, 2010,6, 1405-1408

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Self-assembly hollow nanosphere for enzyme encapsulation

W. Ha, X. Meng, Q. Li, M. Fan, S. Peng, L. Ding, X. Tian, S. Zhang and B. Li, Soft Matter, 2010, 6, 1405 DOI: 10.1039/B925747K

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