Issue 10, 2010
From the journal:

Polymer Chemistry

Synthesis of heterobifunctional poly(ethylene glycol)s by an acetal protection method†

Zhongyu Lia  and  Ying Chau*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
E-mail: ying.chau@ust.hk
Fax: +852-2358 0054
Tel: +852-2358 8935

Abstract

A versatile synthetic route to prepare well-defined heterobifunctional poly(ethylene glycol) (PEG) derivatives via sequential modification of the hydroxyl ends was established using a newly synthesized initiator for anionic polymerization, 2-(1-ethoxyethoxy)ethanol (EEE), which contains an acid-cleavable acetal protection group. As illustrative examples, two heterobifuntional PEGs, HO–PEG–alkyne and HS–PEG–alkyne, were successfully prepared. This approach is applicable for synthesizing a wide variety of heterobifunctional PEGs.

Graphical abstract: Synthesis of heterobifunctional poly(ethylene glycol)s by an acetal protection method

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Article information

DOI
https://doi.org/10.1039/C0PY00310G
Article type
Communication
Submitted
16 Sep 2010
Accepted
11 Oct 2010
First published
22 Oct 2010

Polym. Chem., 2010,1, 1599-1601

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Synthesis of heterobifunctional poly(ethylene glycol)s by an acetal protection method

Z. Li and Y. Chau, Polym. Chem., 2010, 1, 1599 DOI: 10.1039/C0PY00310G

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