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Issue 1, 2010
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Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct?

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Abstract

The universally recognised action spectrum for the UV-induced conversion of 7-dehydrocholesterol to previtamin D3 in human skin was published in 1982, and indicates a maximum at about 297 nm with essentially no production above 315 nm. This work represents a milestone in research on vitamin D, but limitations in the original data should be recognised. Various findings have arisen in recent years which cast doubts on the accuracy of the action spectrum and its application for spectral weighting in calculations of effective UV doses. In conclusion, the construction of an entirely new computational model to predict previtamin D levels is recommended.

Graphical abstract: Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct?

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Publication details

The article was received on 02 Jun 2009, accepted on 16 Sep 2009 and first published on 19 Oct 2009


Article type: Perspective
DOI: 10.1039/B9PP00012G
Photochem. Photobiol. Sci., 2010,9, 11-17

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    Is the action spectrum for the UV-induced production of previtamin D3 in human skin correct?

    M. Norval, L. O. Björn and F. R. de Gruijl, Photochem. Photobiol. Sci., 2010, 9, 11
    DOI: 10.1039/B9PP00012G

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