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Issue 22, 2010
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Synthetic studies on the mycolactone core

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Abstract

Two approaches are presented for the synthesis of the macrolide core of the mycolactone polyketides. The first intertwines ring closing metathesis (RCM) within a two-step Julia olefination protocol, while the second intercepts the optimized routes of Kishi, thereby providing formal access to the mycolactones.

Graphical abstract: Synthetic studies on the mycolactone core

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Publication details

The article was received on 03 Jun 2010, accepted on 17 Aug 2010 and first published on 19 Aug 2010


Article type: Paper
DOI: 10.1039/C0OB00540A
Citation: Org. Biomol. Chem., 2010,8, 5159-5165

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    Synthetic studies on the mycolactone core

    K. Ko, M. D. Alexander, S. D. Fontaine, J. E. Biggs-Houck, J. J. La Clair and M. D. Burkart, Org. Biomol. Chem., 2010, 8, 5159
    DOI: 10.1039/C0OB00540A

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