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Issue 23, 2010
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3-Methoxalylchromone—a novel versatile reagent for the regioselective purine isostere synthesis

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Abstract

The first synthesis of 3-methoxalylchromone was described. The reaction of the latter with electron-rich aminoheterocycles afforded a set of heteroannelated pyridines bearing a CO2Me substituent located at the α-position of the pyridine core.

Graphical abstract: 3-Methoxalylchromone—a novel versatile reagent for the regioselective purine isostere synthesis

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Publication details

The article was received on 05 Jul 2010, accepted on 13 Sep 2010 and first published on 11 Oct 2010


Article type: Communication
DOI: 10.1039/C0OB00379D
Citation: Org. Biomol. Chem., 2010,8, 5280-5284
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    3-Methoxalylchromone—a novel versatile reagent for the regioselective purine isostere synthesis

    S. Mkrtchyan, V. O. Iaroshenko, S. Dudkin, A. Gevorgyan, M. Vilches-Herrera, G. Ghazaryan, D. M. Volochnyuk, D. Ostrovskyi, Z. Ahmed, A. Villinger, V. Ya. Sosnovskikh and P. Langer, Org. Biomol. Chem., 2010, 8, 5280
    DOI: 10.1039/C0OB00379D

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